The USC Gayle and Edward Roski Eye Institute, part of Keck School of Medicine of USC, is a center for ophthalmic care, research and education located in downtown Los Angeles, California. It has subsidiary clinics in Pasadena, Beverly Hills and Arcadia.Alison Trinidad for USC News. December 2, 2014 USC Eye Institute opens new clinic in choice Arcadia location It was allied with the Doheny Eye Institute from 1975 until 2013, when Doheny allied with University of California Los Angeles.

History Ophthalmology at the Keck School of Medicine of USC attained departmental status in 1974 and opened its first building on the USC Health Sciences Campus in 1975. Although an ophthalmology residency program existed at USC prior to that time, there were no full-time faculty members in the department. Stephen J. Ryan was recruited in 1974 and served as the department’s first professor and chairman through 1995. In 1975, the Doheny Eye InstituteHistory . Doheny.org. allied with USC's Ophthalmology department under Ryan and relocated to the USC campus. The alliance "provided Dr. Ryan the opportunity to recruit and build the institute’s department from the ground up. Thus began the transformation of the institute into one of the top university based ophthalmic teaching, clinical, and research centers....Dr. Ryan built Doheny into a respected institution. In 2011 alone, Doheny scientists received $21.8 million in federal and state grants and published more than 180 scientific papers."Linda Roach for Eyenet Magazine. June 2013. The 2012 Academy Laureate, Stephen J. Ryan All of the Doheny Eye Institute's doctors were appointed as USC faculty members.Alex Ortolani For Law360. October 28, 2011 USC Focuses Ire On Eye Institute Over Lease Permits

The Doheny Eye Institute built a new building on USC's campus in 1985 to provide clinical facilities for USC's ophthalmology faculty.University Of Southern California, Plaintiff and Appellant, v. Doheny Eye Institute, Defendant And Respondent. Court Of Appeals Of California, Second District, Division Five. Filed October 18, 2012.

In 2011, USC and the Doheny Eye Institute fell into a dispute over renovations, permits, and other matters related to the building, which led to litigation.

In 2013, the Doheny Eye Institute ended its relationship with USC and entered into an exclusive, long-term affiliation with University of California Los AngelesElaine Schmidt for UCLA News. July 29, 2013 Jules Stein Eye Institute at UCLA and Doheny Eye Institute pursue long-term affiliationEye, Newsletter of the Stein Eye Institute, UCLA. Winter 2014. Stein and Doheny Eye Institute Sign Historic Affiliation Agreement

Ronald E. Smith served as department chairman from 1995 to 2013, and left USC to follow Doheny, and became vice chair of the department at UCLA.

Mark S. Humayun took over as chair of the Department of Ophthalmology at the Keck School of Medicine of USC in November 2013, and in February 2014, Rohit Varma was appointed director of the USC Eye Institute.

In April 2016 it received a $25 million gift from Edward P. Roski and his wife, Gayle, and was renamed in their honor.Kevin Smith for the San Gabriel Valley Tribune. April 5, 2016

Research Members of the Institute have made contributions to vision research, some prior to arriving at USC such as two of the inventors of optical coherence tomography, Carmen A. Puliafito (as of 2007, Dean of the Keck School of Medicine) and David Huang, who did his residency at USC.Eric Swanson for Optical Coherence Tomography News. Mar 29 2009 Ophthalmic Optical Coherence Tomography Market: Past, Present, & FutureJerry Helzner for Ophthalmology Management July 1, 2012 Finding “Big Ideas” in Ophthalmic InnovationHuang lab website Accessed Feb 15, 2015

Dr. Mark Humayun, who joined the faculty of the Keck School of Medicine of USC in 2001,Humayun faculty page at USC Keck Page accessed Feb 15 2015 was a co-inventor of a retinal prosthesis that became the basis for the formation of the company, Second Sight, in 1998.Second SIght. Nov 14, 2014 Second Sight Amendment No. 3 to Form S-1: Registration Statement Their first-generation implant had 16 electrodes and was implanted in 6 subjects by Humayun at University of Southern California between 2002 and 2004; Humayan has participated in subsequent clinical trials as well.Miriam Karmel for Eyenet Magazine, March 2012 Clinical Update: Retina. Retinal Prostheses: Progress and Problems

Ophthalmologist George Baerveldt, while he was at USC, developed the most commonly used glaucoma implant in the world, the Baerveldt glaucoma implant.

In December 2013, David Hinton and Mark S. Humayun won a $19 million grant from the California Institute for Regenerative Medicine to conduct a clinical trial in which the use of embryonic stem cells to treat age-related macular degeneration will be tested.

U.S. News & World Report In 2014-15, USC Eye Institute and USC Department of Ophthalmology retained the No. 9 spot in the national rankings of “Best Hospitals” by U.S. News & World Report. The faculty of the USC Department of Ophthalmology has earned Top 10 recognition by the magazine for 20 years.

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