Mazzone is a surname. Notable people with the surname include:
A. David Mazzone (1928–2004), American lawyer Adolfo Mazzone (1914–2001), Argentine comics artist Carlo Mazzone (1937–2023), Italian football manager Dora Mazzone (born 1967), Venezuelan actress Jason Mazzone (born 1970), American legal scholar Juan Rosario Mazzone, Argentine politician Leo Mazzone (born 1948), American baseball pitcher Luca Mazzone (born 1971), Italian swimmer and cyclist Natasha Mazzone (born 1979), South African politician Noel Mazzone (born 1957), American football player and coach Steven Mazzone (born 1964), American mobster