Michailidis is a surname of Pontic Greek origin. Notable persons with that name include:
Giannis Stergianos-Michailidis (born 1993), Greek football player Chrisostomos Michailidis, (born 1975), Greek football player Ieroklis Michailidis, (born 1960), Greek actor Zinon Michailidis, Greek sport shooter Vasilis Michailidis (1849–1917), Cypriot poet