The Mississippi County Jail was a historic county jail building in Osceola, Arkansas. It was a three-story brick structure, six bays wide, with entrances at the outer two bays, which projected slightly and were set off from the central portion by brick pilasters and a decorative parapet at the roof line. The county built the jail in 1926; it was demolished in 2016.

The building was listed on the National Register of Historic Places in 1987. It was delisted in 2017.

See also National Register of Historic Places listings in Mississippi County, Arkansas

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