James Durham may refer to:
James Derham (1762–1802?), also known as James Durham, the first African American to formally practice medicine in the United States James Durham (baseball) (1881–1949), pitcher in Major League Baseball James Durham (minister), Church of Scotland minister James R. Durham (1833–1904), Union Army officer and Medal of Honor recipient James J. Durham (1849–1920), Baptist minister in South Carolina and the founder of Morris College James O. Durham (born 1864), American politician from Maryland Jim Durham (1947–2012), American sportscaster