Holtzclaw is a surname. Notable people with the surname include:
Bill Holtzclaw (born 1964), American politician Daniel Holtzclaw (born 1986), American former police officer and convicted serial rapist Henry J. Holtzclaw (1897–1969), United States Department of the Treasury official James Holtzclaw, American politician James T. Holtzclaw (1833–1893), American lawyer, railroad commissioner, and Confederate States Army general William Henry Holtzclaw, educator and founder of Utica Institute in Mississippi