Hofheinz is a surname. Notable people with the surname include:
Fred Hofheinz (born 1938), American politician Roy Hofheinz (1912–1982), American judge Roy Hofheinz Jr. (born 1935), American academic and sinologist
See also Margret Hofheinz-Döring (1910–1994), German painter and graphic artist Hofheinz Pavilion, a basketball venue in Houston, Texas