Muižnieks (Old orthography: Muischneek; feminine: Muižniece) is a Latvian language occupational surname. Individuals with the surname include:
Valdis Muižnieks (1935–2013), Latvian basketball player Nils Muižnieks (1964), Latvian-American human rights activist and political scientist Kārlis Muižnieks (1964), former basketball player Vineta Muižniece (1956), Latvian jurist and politician Anete Muižniece-Brice (1962), Latvian former basketball player