Hofmeyr is a surname. Notable people with the surname include:
Genevieve Hofmeyr, South African film producer Gray Hofmeyr (born 1949), South African film and television director Gys Hofmeyr (1871–1942), South African civil servant and the first Administrator of South West Africa Hendrik Hofmeyr (born 1957), South African composer Isabel Hofmeyr (born 1953), South African academic Jan Hofmeyr (disambiguation), multiple people Murray Hofmeyr (1925–2018), South African rugby union player and cricketer Steve Hofmeyr (born 1964), South African singer, songwriter and actor Willie Hofmeyr (born 1954), South African lawyer and politician