Santamarina is a surname. Notable people with the surname include:
Ángel Santamarina, Argentine fencer Eduardo Santamarina (born 1968), Mexican actor Enrique Santamarina (1870–1937), Argentine politician José Santamarina (born 1963), Argentine rugby union player Luis Santamarina (1942–2017), Spanish cyclist Mercedes Santamarina (1896–1972), Argentine art collector Ramon Santamarina (1827–1904), Argentine businessman
See also Club y Biblioteca Ramón Santamarina or Santamarina, a football club named for the Argentine businessman, in Tandil, Buenos Aires Province Santa Marina (disambiguation)