Pentacyphus is a genus of plants in the family Apocynaceae, first described as a genus in 1906.Tropicos, genus Pentacyphus Schlechter, Friedrich Richard Rudolf. 1906. Botanische Jahrbücher für Systematik, Pflanzengeschichte und Pflanzengeographie 37: 605–606 in Latin with short commentaries in German It is native to South America (Bolivia, Colombia, Ecuador, Peru and Venezuela).Idárraga-Piedrahita, A., R. D. C. Ortiz, R. Callejas Posada & M. Merello. (eds.) 2011. Flora de Antioquia: Catálogo de las Plantas Vasculares 2: 9–939. Universidad de Antioquia, MedellínMorillo, G. 1994. Fontellaea, gen. nov., y otras novedades o aportaciones en Asclepiadaceae andinas. Anales del Jardín Botánico de Madrid 52(1): 33–41Morillo, G. 1993. Asclepiadaceae andinas nuevas o interesantes. Acta Botanica Venezuelica 16(2/4): 55–71.Holm, R. W. 1950. The American species of Sarcostemma R. Br. (Asclepiadaceae). Annals of the Missouri Botanical Garden 37(4): 477–560
Species , Plants of the World Online accepted three species: Pentacyphus andinus (Ball) Liede – Bolivia, Peru Pentacyphus camargoi (Morillo) Meve & Liede – Colombia Pentacyphus lehmannii (Schltr.) Liede – Colombia, Ecuador, Venezuela
Formerly included Pentacyphus tamanus (Morillo) Liede, synonym of Pentacyphus lehmannii subsp. tamanus
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