Palepoi is a Samoan surname. Notable people with the surname include:
Anton Palepoi (born 1978), American football player, brother of Tenny Palepoi Opeta Palepoi (born 1975), Samoan rugby union player Tenny Palepoi (born 1990), American football player, brother of Anton Palepoi Mauga Palepoi (died 1963), American Samoan politician