Guzik is a Polish surname meaning "button". Notable people with the surname include:
Alberto Guzik (1944–2010), Brazilian actor Anna Guzik (born 1976), Polish actress Grzegorz Guzik (born 1991), Polish biathlete Jake Guzik (1886–1956), American mobster John Guzik (linebacker) (1936–2012), American football player John Guzik (defensive lineman) (born 1962), American football player Jolanta Guzik (born 1981), Polish chess master Martin Guzik (born 1974), Czech footballer Tomasz Guzik (born 1974), Polish scientist