Arkhypenko (), also transliterated as Arkhipenko or Archipenko, is a Ukrainian-language family name of patronymic derivation from the Slavic first name Arkhyp/Arkhip (),derived from the Greek name Archippus. The Belarusian-language version is Arkhipienka.
The surname may refer to: Alexander Archipenko (1887–1964), Ukrainian artist Eugene Archipenko (1884–1959), Ukrainian politician and agronomist Fyodor Arkhipenko (1921–2012), Soviet-Belarusian flying ace Vasyl Arkhypenko (born 1957), Soviet-Ukrainian athlete
See also
6535 Archipenko, asteroid