A scalpel is a surgical instrument used for cutting.

Scalpel may also refer to:

SCALPEL, a laser-guided bomb produced by Lockheed Martin The Scalpel, a commercial skyscraper in London, United Kingdom Scalpel (film), a 1977 American thriller film Laser scalpel, a scalpel which uses a laser, not a blade, for cutting SS-24 Scalpel, an intercontinental ballistic missile Scalpel, a character in the Transformers film series "Scalpel", a song by Alice In Chains from The Devil Put Dinosaurs Here