Blassingame is a surname. Notable people with the surname include:
Jerel Blassingame (born 1981), American professional basketball player John Wesley Blassingame (1940–2000), American historian and writer Lurton Blassingame (1904–1988), American literary agent Tia Blassingame (born 1971), American artist William Blassingame (1836–?), American politician Wyatt Rainey Blassingame (1909–1985), American author