Gargano is an Italian surname. Notable people with the surname include:
Andrea Gargano (1887–1970), Italian sport wrestler Camillo Gargano (1942–1999), Italian sailor Charles A. Gargano (born 1934), Italian-born American diplomat Francesco Gargano (1899–1975), Italian fencer Giuseppina Gargano (1853-1939), Italian opera singer Johnny Gargano (born 1987), American wrestler Maria Teresa Gargano (born 1986), Italian artistic gymnast Margherita Gargano (born 1952), Italian middle-distance runner Mario Gargano (died 2018), Italian politician Nicholas Gargano (1934–2016), English boxer Reinaldo Gargano (1934–2013), Uruguayan politician Walter Gargano (born 1984), Uruguayan footballer