De Graff may refer to:

People Arthur C. DeGraff (1899–1983), American cardiologist Devaun DeGraff (born 1980), Bermudian footballer Geoffrey de Graff (born 1949), secular name of American monk Ṭhānissaro Bhikkhu Jeff DeGraff (born 1958), American professor, author, and consultant John I. De Graff (1783–1848), American politician Laurens de Graaf (1653–1704), Dutch pirate Lawrence De Graff (1871–1934), American judge Peter DeGraaf (born 1957), American politician Robert Fair de Graff (1895–1981), American publisher, founder of Pocket Books

Places In the United States: De Graff, Kansas, an unincorporated place in Butler County, Kansas De Graff, Minnesota, a city in Swift County, Minnesota, United States De Graff, Ohio, a village located in Logan County, Ohio, United States