ISSC stands for the International Social Science Council, a non-governmental organization set up by the United Nations.

ISSC may also refer to:

Education Interdisciplinary School of Scientific Computing, at the University of Pune, India Instituto Salesiano Student Council, at the Instituto Salesiano, Macau

Business Isles of Scilly Steamship Company, a UK transportation company Integrated Systems Solution Corporation, an IBM computer services subsidiary, precursor of IBM Global Services ISSC Technologies, a Taiwan-based developer of Bluetooth system on chip solutions, acquired in 2014 cby Microchip Technology#ISSC Technologies

Others Interstate Shellfish Sanitation Conference, a US federal organization International Super Sportscar Circuit, at Rockingham Motor Speedway, UK The Informatics and Statistics Science Collaboration of the Large Synoptic Survey Telescope U.S. Army Information Systems Software Center, a former center in the United States Army Communications-Electronics Command

See also ISCC (disambiguation) ISC (disambiguation) International Solid-State Circuits Conference (ISSCC)