Scio or SCIO may refer to:
Places Chios (Genoese: Scio), a Greek island in the Aegean Sea
United States Scio, New York, a town Scio (CDP), New York, the primary settlement in the town Scio, Ohio Scio, Oregon Scio Township, Michigan Scio, Michigan, an unincorporated community
Other uses Science Olympiad, an American elementary, middle, and high school team competition that focuses on various science topics and engineering ability Scottish charitable incorporated organisation, a type of charity in Scotland State Council Information Office, external name of the Central Propaganda Department of the Chinese Communist Party