William Boone may refer to:
William Boone (American football) (1879–1963), American football coach in the United States William E. Boone (1830–1921), American architect William K. Boone (1875–1944), benefactor of Xalapa, Veracruz William Boone (mathematician) (1920–1983), American mathematician William Jones Boone (father) (1811–1864), first Anglican missionary bishop of Shanghai William Jones Boone (son) (1845–1891), fourth Anglican missionary bishop of Shanghai John William Boone (1864–1927), American ragtime music composer