PRB may refer to:
Companies and organizations Periodic Review Board Population Reference Bureau Poudreries Réunies de Belgique, former Belgium armaments manufacturer PRB (company), Australian Automotive Manufacturer PRB, French Coatings Company Pre-Raphaelite Brotherhood of artists PRB Sailing Team Polish Business Council (Polska Rada Biznessu in Polish)
Politics Brazilian Republican Party (Partido Republicano Brasileiro, in Portuguese) Parti Rakyat Brunei, former political party in Brunei
Science Retinoblastoma protein, pRb, an important tumour-suppressor gene in retinoblastoma Progesterone receptor B
Other uses Paso Robles Municipal Airport, IATA designation People’s Republic of Bangladesh People's Republic of Benin People's Republic of Bulgaria Permeable reactive barrier, for groundwater remediation Physical Review B, physics journal Powder River Basin, US PRB (vessel) The unofficial ISO 4217 code for the Transnistrian rubla