Gastélum is a surname. Notable people with the surname include:
Alejandra León Gastélum (born 1976), Mexican politician Bernardo J. Gastélum (1886–1981), Mexican physician, politician and writer Diva Hadamira Gastélum (born 1961), Mexican politician Jorge Gastélum (born 1988), Mexican footballer Juan Manuel Gastélum (1954–2025), Mexican politician Kelvin Gastelum (born 1991), American mixed martial artist