De Cuyper is a surname, equivalent to English Cooper. Notable people with the surname include:
Alphons De Cuyper (1887–1950), Belgian sculptor and painter Katrien De Cuyper (1967–c. 1991), Belgian homicide victim Norbert De Cuyper (b. 1943), Belgian politician Simon De Cuyper (b. 1986), Belgian triathlete
See also De Kuyper