Sisco or Sisko may refer to:
Places Sisco, Haute-Corse, Corsica, France, a commune Sisco (stream), Corsica, France, which flows through the commune Sisco, Florida, United States, a ghost town Sisco Mesa, Antarctica
People Andrew Sisco (born 1983), American baseball pitcher Chance Sisco (born 1995), American baseball catcher David Sisco (1937–2016), American NASCAR driver Gary Sisco, American government administrator, 29th Secretary of the United States Senate Jack Sisco (1904–1983), American football player, coach and official Jordan Sisco (born 1998), Canadian football player Joseph J. Sisco (1919–2004), American diplomat Kristina Sisco (born 1982), American writer and former actress Marideth Sisco (1943–2026), American storyteller, folklorist, singer-songwriter, author and retired journalist Tauna S. Sisco, American sociologist Sisco Gomez, stage name of English dancer and choreographer Francisco Gomez-Aspron (born 1985)
Fictional characters Karen Sisco, a United States Marshal created by novelist Elmore Leonard, also appearing in a television series and the film Out of Sight From the television series Star Trek: Deep Space Nine: Benjamin Sisko Jake Sisko Jennifer Sisko Joseph Sisko
See also Sisqó (born 1978), American R&B singer, songwriter, record producer, dancer and actor Gene Siskel (1946–1999), American film critic and journalist Cisco, a technology corporation