Sulfinalol is a beta adrenergic receptor antagonist.
Synthesis
The preparation of sulfinalol begins by protection of the phenolic hydroxyl as its benzoate ester. Bromination followed by condensation with 4-(4-methoxyphenyl)butan-2-amine gives the amino ketone 3. Successive catalytic reduction and saponification affords amino alcohol 4. Oxidation of the sulfide to the sulfoxide with a reagent such as metaperiodate gives sulfinalol (5).
The methyl group on a sulfoxide is sufficiently acidic to substitute for phenolic hydroxyl.
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