Bunitrolol is a beta-adrenergic antagonist. Synthesis
2-Hydroxybenzonitrile (1) is treated with epichlorohydrin and sodium hydroxide to give the epoxide (2). Addition of tert-butylamine completes the synthesis of bunitrolol.Herbert Koppe, Albrecht Engelhardt, Karl Zeile, (1976 to Boehringer Ingelheim Gmbh).
See also Bucindolol Epanolol Cyanopindolol References