The following is a list of actors, and the characters they played, who appeared in the Telemundo series El Señor de los Cielos.
Main characters Rafael Amaya as Aurelio Casillas (seasons 1–10; guest season 7): the main protagonist of the series, Head of the Casillas Cartel, and the patriarch of the Casillas family. Great-grandson of Teodoro Valenzuela. Ximena Herrera as Ximena Letrán (seasons 1–2): Aurelio's wife, and Rutila, Luzma and Heriberto's mother. Don Cleto's daughter. Robinson Díaz as Miltón Jiménez / Pío José Valdivia "El Cabo" (season 1, 6-7, 9; recurring season 2 and 8; special guest stars season 5): is the main distributor of drugs in Colombia, former partner of El Tijeras, Don Oscar's second-in-command and right-hand man. Leader of the North Valley Cartel after Don Oscar and Head of Rastrojos Cartel, and the main enemy of Aurelio. In season 7 after escaping from the authorities, he changes his name to Pío José Valdivia. Associate of the Caborca Cartel. Raúl Méndez as Víctor Casillas "Chacorta" (seasons 1–2): Aurelio's brother, father of Victor and Carlos, Aurelio's second-in-command and right-hand man. One of the leaders of the Casillas Cartel. Gabriel Porras as Marco Cartagena Mejía (season 1): Police Officer obsessed with capturing Aurelio Casillas for the death of his father DEA Agent Eduardo Cartagena. Commander of Federal Police and National Anti-Drug Commissioner. Carmen Villalobos as Leonor Ballesteros Mirelys (seasons 1–3): Colombian infiltrated agent and the female protagonist of the series during seasons 2–3. Later Omar's wife. Mauricio Ochmann as José María Venegas Mendivíl "El Chema" (seasons 2–3; special guest stars season 1): Former enforcer of the Sonora Cartel. Founding Member and Head of the Venegas cartel, Leonardo and El Chemita's father, El Rojo's adoptive brother, Rutila's lover, Aurelio's ally and rival, Fabricio Ponce's enemy, Ricardo Almenar's enemy. Alberto Guerra as José María Venegas Mendivíl "El Chema" (season 6; recurring season 7) Fernanda Castillo as Mónica Robles Urdieta (seasons 2–5; recurring season 1; she also made guest appearance in El Chema) Isidro and Guadalupe's sister. Last leader of the Robles Cartel. Isidro's mother. Aurelio's lover, ally and rival. Marlene Favela as Victoria Navárez "La Gober" (season 2), Daughter of Governor Pedro Navárez and later Governor of Jalisco. Carmen Aub as Rutila Casillas Letrán (seasons 3–10; recurring season 2; she also made guest appearance in El Chema), Heriberto's and Luzma's sister. Ismael, Niky and Nazareno's half-sister. Daughter of Aurelio and Ximena. Don Cleto's grand-daughter. El Chemita/Humberto's mother. Former leader of the Letrán Cartel after Don Cleto then becoming one of the leaders of the Casillas Cartel. Former associate of the Venegas Cartel and Robles Cartel. Terina Angell as Child Rutila (season 1) Ana Sofía Durán as Child Rutila (season 2) Maritza Rodríguez as Amparo Rojas (seasons 3–4): Matilde's late sister and Aunt of Carlos. Sabrina Seara as Esperanza Salvatierra Cortini (seasons 4–5, recurring season 3), Aurelio's Ex-lover. Former associate of Casillas Cartel. Vanessa Villela as Emiliana Contreras Cortenas (seasons 4–5; she also made guest appearance in El Chema):, Lencho's daughter. Marisela González as Eunice Lara "La Felina" (seasons 5-10, recurring season 4; Main role in Season 2 of La Doña): El Super Javi and La Doña's parther. Don Feyo, El Oficial and El Duro's lover. Associate of the Knights Templar Cartel, Casillas Cartel and Sandoval's Construction Company. Mariana Seoane as María Isabel "Mabel" Castaño / Ninón del Valle (season 5; reprising her role from El Chema). El Chema's former lover, Gary's Widow. Leonardo's Mother. Aurelio's lover after Pilar. Mónica and Felina's rival and enemy. Miguel Varoni as Leandro Quezada (season 5–6; reprising his role from Dueños del paraíso): Head of the Santa Norma Cartel. Guy Ecker as Joe Navarro (season 6–7): US National Anti-Drug Commissioner and the DEA station chief in México after Colon. Ninel Conde as María de los Ángeles "Evelina" López (season 6–7): El Rayo's missing daughter. El Cabo and Joaquín's lover. Carlos Bardem as Leonidas "El Chivo" Ahumada (season 6), Former Candidate of the Governor of Coahuila. Diana and Berenice's father. Alejandro López Silva as El Súper Javi (season 6-8; recurring seasons 3–5, 7; he also made guest appearance in El Chema): Commander of the FARC and later Casillas Cartel. Rutila's lover. Jesús Moré as Omar Terán Robles (season 6; recurring seasons 3–5; he also made guest appearance in El Chema): Corrupted politician. Leonor's husband. Former Ministry of Health and 64th President of México after Morejon. Relative of the Robles Family. Affiliate of the Robles Cartel, Casillas Cartel and Rastrojos Cartel. Lisa Owen as Doña Alba Casillas (season 6; recurring seasons 1–3, 5, 7, guest season 8): Don Humberto's widow. Aurelio's and Chacorta's mother. Granddaughter Teodoro Valenzuela. Isabella Castillo as Diana Ahumada (seasons 6–10): Esther and El Chivo's daughter, Berenice's older sister and Amado's girlfriend. High-ranking member of the Casillas Cartel. Matías Novoa as Amado Casillas Leal "El Águila Azul" (season 6–7): Aurelio's half-brother, and Diana's boyfriend, former agent of the CIA becoming one of the leaders of the Casillas Cartel. Iván Arana as Ismael Casillas Guerra (seasons 6–9; recurring seasons 4–5; he also made guest appearance in El Chema): The missing son of Aurelio, Aurelio's right hand man and second-in-command of the Casillas Cartel from seasons 5-8. One of the leaders of the Casillas Cartel. Fernando Noriega as Eutimio "Rojo" Flores (season 6; recurring seasons 5, 7; reprising his role from El Chema): El Chema's Former right hand and second-in-command of the Venegas Cartel. Super Javi's ally. Founding member and former leader of the Venegas Cartel and later high-ranking member of the Casillas Cartel. Eduardo Santamarina as Balthazar Ojeda (season 7; recurring season 6): Former Agent of the CIA, High-ranking Member and Double Agent of the Balcanes Cartel and Rastrojos Cartel, Renzo Volpi's associate and brief right hand man, El cabo new ally/partner and second-in-command, and amado's arch-enemy. Danna García as Violeta Estrella (season 7): Joaquín's Wife Rubén Cortada as Fernando Aguirre (season 8): Corrupt businessman and serial killer, Don Julio's right man and second-in-command. Leader of the Caborca Cartel after Don Julio. África Zavala as Mercedes "Mecha" de la Cruz (seasons 8–9): Another one of the Aurelio's lovers. Yuri Vargas as Tracy Lobo (season 8): Corrupted infiltrated DEA agent obsessed with capturing Aurelio Casillas, main person responsible for the desecration of the tomb and resurrection of Aurelio Casillas alongside boss Manzano, she is an expert in torturing criminals and infiltrations, planning to run all agency operations in Mexico. Salma/Corina's rival and arch-enemy. Itatí Cantoral as Belén San Román / Blanca Lovato (season 9; reprising her role from El Chema) Julio Bracho as Ricardo Almenar (season 9; reprising his role from El Chema) Jason Romo as Diego Bustamante (season 9)
Recurring characters Introduced in season 1 Andrés Parra as Pablo Escobar (repirsing his role from Pablo Escobar, The Drug Lord): Colombian drug trafficker and head of the Medellín Cartel. Sara Corrales as Matilde Rojas (seasons 1–2): Chacorta's wife. Amparo's deceased sister and mother of Carlitos. Fernando Solórzano as Don Óscar Cadena (repirsing his role from El cartel and also portrayed the role in El Chema): Colombian drug trafficker and head of the North Valley Cartel. El Tostado's former rival. Associate of the Venegas Cartel, Casillas Cartel and later Galván Cartel. Arturo Barba as Alí Benjuema "El Turco" (seasons 1–2): Aurelio's legal adviser. Ximena's lover. Affiliate of the Casillas Cartel, Galván Cartel and later Venegas Cartel. Sophie Gómez as Irina Vorodin (seasons 1–2): El Turco's partner. Affiliate of the Casillas Cartel and North Valley Cartel. Juan Ríos Cantú as General Daniel Jiménez Arroyo "El Letrudo" (he also made guest appearances in El Chema): Corrupt Militar, Aurelio and Chacorta's accomplice and parther. Fabricio Ponce and Marco Mejia's boss government colleagues. Affiliate of the Casillas Cartel. Angélica Celaya as Eugenia Casas: Journalist. Marco's girlfriend. Guillermo Quintanilla as Isidro Robles Urdieta (he also portrayed the role in El Chema): Mónica and Guadalupe's brother. Eldest of the Robles Family and Head of the Robles Cartel. Marco Pérez as Guadalupe Robles Urdieta (he also made guest appearances in El Chema): Mónica and Isidro's brother, second-in-command of the Robles cartel. One of the leaders of the Robles Cartel, Aurelio's enemy. Rocío Verdejo as Doris de Jiménez: El Letrudo's wife. Tommy Vásquez as Álvaro José Pérez "Tijeras" (seasons 1–4): El Cabo's partner and right hand man. second-in-command of the North Valley Cartel, Becoming one of the leaders of the North Valley Cartel after Don Oscar and later Envigado/Rastrojos cartel. Fabián Peña as Jesús Linares: Eugenia's friend. Emmanuel Orenday as Gregorio Ponte Hernández (seasons 1–2): Marco and Leonor's partner in the Federal Police. Ruy Senderos as Heriberto Casillas Letrán (seasons 1–2): Aurelio's Eldest son, third-in-command of the Casillas Cartel. High-ranking member of the Letrán Cartel and Casillas Cartel. Bianca Calderón as Roxana Mondragón (she also made guest appearances in El Chema): Isidro's girlfriend. Guadalupe's lover. Ángel Cerlo as General Castro: a corrupt politician. Affiliate of the Casillas Cartel Arnoldo Picazzo as Flavio Huerta: a corrupt politician. Affiliate of the Robles Cartel and Casillas Cartel. Juan Ignacio Aranda as Ramiro Silva de la Garza (seasons 1, 3–4; he also portrayed the role in El Chema): a corrupt politician. Ricardo Almenar and Tobias Clark's adviser. Aurelio's associate. Omar Teran's Mentor. Living in Dublin. Affiliate of the Sonora Cartel and Casillas Cartel. Jorge Zárate as Juan Montoya: Mexican drug trafficker from Tamaulipas. Leader of the Villalobos cartel. Javier Díaz Dueñas as Don Anacleto "Cleto" Letrán (he also made guest appearance in El Chema): Ximena's father, Drug Lord From Sinaloa and Aurelio's father-in Law. Aurelio and Chacorta's former mentor. Head of the Letrán Cartel. Manuela González as Lorelay "Lay" Cadena (seasons 1–2): Matilde's partner. Aurelio's ex-lover. Don Oscar's late sister. Fernando Banda as Agustín Chon "El Vitaminas" (season 1–present): Aurelio's bodyguard and right hand man. Enforcer of the Casillas Cartel. Carlos Gallardo as Patólogo (season 1) / Carlos José Zuleta (season 5–6): Chief of Estado Mayor Presidencial and El Cabo's adviser. Enforcer of the Rastrojos Cartel. Rodrigo Abed as César Silva de la Gárza (he also made guest appearances in El Chema): the 60th President of México. Roberto Uscanga as Arturo Benitez: Former Ministry of the Interior later becomes 61st President of Mexico after Cesar Silva. Iñaki Goci as El Triste (he also portrayed the role in El Chema): Chief of Security for the Robles Cartel, Isidro's bodyguard and right man of the Robles Cartel. Enforcer of the Robles Cartel.
Introduced in season 2 Erika de la Rosa as Elsa Marín: Corrupt Politician. She is National Attorney and later The Mayor of Guadalajara. El Chema's parther. Defeated candidate for Governor of Jalisco. Affiliate of the Venegas Cartel. Ari Brickman as Jeremy Andrews (seasons 2–3; he also portrayed the role in El Chema): high ranking DEA Agent and later station chief in México after Jones. El Chema's adviser. Double Agent and Enforcer of the Venegas Cartel. Carlos Torrestorija as Maximiliano "Max" Miravalle: Ignacio's father. Elsa's lover. Tomás Goros as General Antonio Garnica (seasons 2–4): Former Head of the anti-drug Division. Corrupt General enemy of Aurelio. General of the Emes.