The following railroads operate in the U.S. state of Mississippi.
Common freight carriers Alabama and Gulf Coast Railway (AGR) Alabama Southern Railroad (ABS) BNSF Railway (BNSF) Canadian National Railway (CN) through subsidiary Illinois Central Railroad (IC) Columbus and Greenville Railway (CAGY) Canadian Pacific Kansas City (CPKC) CSX Transportation (CSXT Golden Triangle Railroad (GTRA) Grenada Railway (GRYR) Luxapalila Valley Railroad (LXVR) M&B Railroad (MNBR) Meridian Southern Railway (MDS) Mississippi Central Railroad (MSCI) Mississippi Delta Railroad (MSDR) Mississippi Export Railroad (MSE) Mississippi Southern Railroad (MSR) Mississippian Railway (MSRW) Natchez Railway (NTZR) Norfolk Southern Railway (NS) including subsidiary Alabama Great Southern Railroad (AGS) Old Augusta Railroad (OAR) Port Bienville Railroad (PBVR) Ripley and New Albany Railroad (RNA) R.J. Corman Railroad/Tennessee Terminal (RJCK) Vicksburg Southern Railroad (VSOR) West Tennessee Railroad (WTNN)
Passenger carriers
Amtrak (AMTK)
Defunct railroads