Madre de Deus was a Portuguese treasure ship captured by English privateers in 1592.

Madre de Deus (Portuguese for Mother of God) may also refer to:

Municipalities in Brazil Madre de Deus, Bahia Madre de Deus de Minas, Minas Gerais Brejo da Madre de Deus, Pernambuco

Buildings and landmarks Monastery of Madre de Deus, a location of the National Azulejo Museum in Lisbon, Portugal Madre de Deus Convent, a former convent and church, now the National Museum of the Azulejo in Lisbon, Portugal Madre de Deus Manor, a landmark in the Azores, Portugal Mother of God Church, Vettukad, Kerala, India

Other Filipe da Madre de Deus (ca.1630–1688x90) Portuguese composer An alternate name for the Portuguese ship Nossa Senhora da Graça

See also Madredeus, a Portuguese musical ensemble Madre de Dios (disambiguation) same title in Spanish