This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.

Very common Very common (10-100% incidence) adverse effects include: Nausea Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs. Impaired concentration Somnolence is more common with paroxetine than with other SSRIs. Insomnia Headache Dry mouth

Common Common (1-10% incidence) adverse effects include:

Changes in appetite Dyspepsia (indigestion) Tooth disorder Stomatitis Oropharyngeal disorder Flatulence Impaired urination Urinary frequency Agitation Abnormal dreams (including intense dreams or nightmares) Hypercholesterolaemia (elevated blood cholesterol) Dizziness Tremor Blurred vision Yawning Diarrhoea which is less common with paroxetine than with other SSRIs. Constipation (if chronic may lead to hemorrhoids) Vomiting Anxiety Nervousness Hypomania, may occur in as many as 8% of patients being treated with paroxetine. May be more common in those with bipolar disorder. Asthenia Weight gain or loss. Usually gain, paroxetine tends to produce more weight gain than other SSRIs. Confusion Emotional lability Myoclonus Myopathy Myalgia Myasthenia Drugged feeling Hyperthesia Respiratory disorder Pharyngitis Increased cough Rhinitis Taste perversion Abnormal vision Pruritus (itching) Sweat gland disorder Abdominal pain Fever Chest pain Trauma Back pain Malaise Pain Palpitations Vasodilatation Postural hypotension (a drop in blood pressure upon standing up) Hypertension (high blood pressure) Syncope (fainting) Tachycardia (high heart rate)

Uncommon Uncommon (0.1-1% incidence) adverse effects include:

Abnormal bleeding, predominantly of the skin and mucous membranes (mostly ecchymosis) Confusion Hallucinations Extrapyramidal disorders (which occurs more commonly in paroxetine-treating patients than patients treated with other SSRIs) Sinus tachycardia Transient changes in blood pressure Urinary retention Urinary incontinence Allergic reaction Chills Face oedema Infection Bradycardia Conduction abnormalities Abnormal ECG Hypotension Ventricular extrasystoles Acne Alopecia (hair loss) Dry skin Eczema Furunculosis Herpes simplex Urticaria Bruxism Buccal cavity disorders Dysphagia Eructation Gastroenteritis Gastrointestinal flu Glossitis Increased salivation Abnormal liver function tests Mouth ulceration Rectal haemorrhage Miscarriage Amenorrhoea (lack of menstrual cycles) Breast pain Cystitis Dysmenorrhoea Dysuria Menorrhagia Nocturia Polyuria Urinary tract infection Urinary urgency Vaginitis Anaemia Leucopenia Lymphadenopathy Purpura White blood cell abnormality Oedema Hyperglycaemia (high blood sugar) Peripheral oedema Thirst Arthralgia Arthritis Traumatic fracture Abnormal thinking Akinesia Alcohol use disorder Amnesia (memory loss) Ataxia Convulsion Lack of emotion Paranoid reaction Asthma Bronchitis Dyspnoea (air hunger) Epistaxis Hyperventilation Pneumonia Respiratory flu Sinusitis Abnormality of accommodation Conjunctivitis Ear pain Eye pain Mydriasis Otitis media Tinnitus Keratoconjunctivitis

Rare Rare (0.01-0.1% incidence) adverse effects include:

Mania, may be more common in those that either have or have a family history of bipolar disorder. Depersonalisation Panic disorder Akathisia Restless legs syndrome Elevated liver enzymes Hyperprolactinaemia (elevated serum prolactin) Galactorrhoea (lactation that is not associated with pregnancy or breastfeeding) Abnormal laboratory value Abscess Adrenergic syndrome Cellulitis Chills and fever Cyst Hernia Intentional overdose Neck rigidity Pelvic pain Peritonitis Substernal chest pain Ulcer Angina pectoris Arrhythmia Atrial arrhythmia Atrial fibrillation Bundle branch block Cerebral ischaemia Cerebrovascular accident (stroke) Congestive heart failure Extrasystoles Low cardiac output Myocardial infarct (heart attack) Myocardial ischaemia Pallor Phlebitis Pulmonary embolus Supraventricular extrasystoles Thrombophlebitis Thrombosis Varicose vein Vascular headache Angioedema Contact dermatitis Erythema nodosum Herpes zoster Hirsutism Maculopapular rash Photosensitivity Skin discolouration Skin ulcer Diabetes mellitus Hyperthyroidism Hypothyroidism Thyroiditis Aphthous stomatitis Bloody diarrhoea Bulimia Colitis Duodenitis Oesophagitis Faecal impaction Faecal incontinence Gastritis Gingivitis Haematemesis (vomiting blood) Hepatitis Ileus Jaundice Melaena (black faeces as a result of bleeding in the stomach) Salivary gland enlargement Stomach ulcer Stomatitis Tongue oedema Tooth caries Tooth malformation Breast atrophy Female lactation Haematuria (blood in the urine) Kidney calculus (kidney stones) Abnormal kidney function Kidney pain Mastitis Nephritis Oliguria Urethritis Urine abnormality Vaginal candidiasis Eosinophilia Iron deficiency anaemia Leucocytosis Lymphoedema Lymphocytosis Microcytic anaemia Monocytosis Normocytic anaemia Increased alkaline phosphatase Bilirubinaemia Dehydration Gout Hyperphosphataemia (elevated levels of phosphate in the blood) Hypocalcaemia (low blood calcium) Hypoglycaemia (low blood sugar) Hypokalaemia (low blood potassium) Hyponatraemia (low blood sodium) Obesity Arthrosis Bursitis Cartilage disorder Myositis Osteoporosis (brittle bones) Tetany Abnormal electroencephalograph Abnormal gait Choreoathetosis Circumoral paraesthesia Delirium Delusions Diplopia Drug dependence Dysarthria Euphoria Fasciculations Grand mal convulsions Hyperalgesia Hysteria Increased libido Manic depressive reaction Meningitis Myelitis Neuralgia Neuropathy Nystagmus Psychosis Psychotic depression Increased reflexes Stupor Withdrawal syndrome Hiccup Lung fibrosis Increased sputum Voice alteration Emphysema Pulmonary oedema Amblyopia Specified cataract Conjunctival oedema Corneal lesion Corneal ulcer Exophthalmos Eye haemorrhage Glaucoma Hyperacusis Otitis externa Photophobia Retinal haemorrhage (bleeding into the retina) Taste loss Anisocoria Deafness Activation syndrome

Very rare Rare (<0.01% incidence) adverse effects include: Thrombocytopenia Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) Serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor) Gastrointestinal bleeding Hepatic events (such as hepatitis, sometimes associated with jaundice and/or liver failure) Priapism Severe cutaneous adverse reactions (including erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis) Photosensitivity reactions

References