The 2005–06 Louisville Cardinals men's basketball team represented the University of Louisville in the 2005–06 NCAA Division I men's basketball season. The head coach of the Cardinals was Rick Pitino.
Louisville defeated Miami 58–43 in the Orange Bowl Basketball Classic on December 31, 2005, improving to 11–1 on the season.
The Cardinals finished with a 21–13 record. They were eliminated from the ACC tournament in the first round by Pittsburgh 61–56 on March 8, 2006. Their season ended after a 78–63 loss to South Carolina in the 2006 NIT semifinals on March 28, 2006.
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