Frank Costello (1891–1973) was an Italian-American crime boss of the Luciano crime family.
Frank Costello may also refer to:
Frank Costello (The Departed) Frank Costello (footballer) (1884–1914), English footballer Frank Gibson Costello (1903–1987), architect in Australia Frank Costello (high jumper), winner of the 1965 high jump at the NCAA Division I Indoor Track and Field Championships