Eugene Sweeney (1592–1669) was an Irish prelate of the Roman Catholic Church who served as the Bishop of Kilmore from 1629 to 1669.

A native of County Donegal, he was appointed the Bishop of the Diocese of Kilmore by Pope Urban VIII on 18 September 1629., Handbook of British Chronology, p. 436., A New History of Ireland, volume IX, p. 349.

He died in office on 18 October 1669, aged 77. After his death, the see remained vacant for nearly sixty years, during which time it was administered by vicars general or bishops of Clogher.

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