Hermosilla is a Spanish surname. Notable people with the surname include:
Edmundo Hermosilla (born 1956), Chilean politician Ireneo Hermosilla (1928–2003), Paraguayan footballer Julia Hermosilla (1916–2009), Basque activist and resistance fighter Miguel Hermosilla (1948–2019), Chilean footballer and manager
See also José Mamerto Gómez Hermosilla (1771–1837), Spanish Hellenist, journalist and writer Estadio Luis Valenzuela Hermosilla, a multi-use stadium in Copiapó, Chile