The 2005–06 EHF Women's Cup Winners' Cup was the 30th edition of EHF's competition for women's handball national cup champions. It ran from October 1, 2005 to May 20, 2006.
1985 champion Budućnost Podgorica, now representing Serbia and Montenegro, won its third European trophy and the first one since the break-up of Yugoslavia, beating Győri ETO, which defeated defending champion Larvik HK in the semifinals. It was Győri ETO's fourth lost European final in five years.Results in EHF's website
Results First preliminary round. October 1–9, 2005 Local teamAggregateAway team1st leg2nd leg McDonald's Wiener Neustadt 51–41 Zeeman Vestgoed 29–21 22–20 Váci NKSE 60–52 SKP Banská Bystrica 33–24 27–28 Assomada Carnaxide 47–81 HC Naisa 22–38 25–43 Vicianet Mitrovice 29–85 Bayer Leverkusen 13–44 16–41 UMF Stjarnan 66–67 Anadolu Üniversitesi 39–34 27–33 Zaglebie Lubin 73–39 Gjorče Petrov Skopje 30–16 43–23 Amicitia Zürich 48–37 Sporting Neerpelt 25–19 23–18 Rapid Bucharest 97–33 CS Baracuda 52–13 45–20 Galychanka Lviv 50–54 Ormi Patras 26–27 24–27 Sola HK 90–26 SPES Kefalovrysos 53–11 37–15 Kuban Krasnodar 72–43 Celeia Zalec 38–27 34–16 SD Itxako 83–15 Hapoel Kiryat Ono 40–10 43–5
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