Pennefather is a surname. Notable people with the surname include:
Alice Pennefather (1902–1983), Singaporean sportswoman David Pennefather (born 1945), British military figure; former Commandant General, Royal Marines Edward Pennefather (1775–1847), Irish judge Joan Pennefather, Canadian film and cultural executive Sir John Pennefather (1798–1872), British soldier who won two very remarkable victories Sir John Pennefather, 1st Baronet (1856–1933), British cotton merchant and Conservative politician Percy Pennefather (1923–1975), Singaporean field hockey player Richard Pennefather (judge) (1773–1859), Irish judge who conducted the Doneraile Conspiracy Trials of 1829 Richard Pennefather (Australian politician) (1851–1914), 9th Attorney-General of Western Australia Rupert Pennefather (born 1981), English dancer; principal dancer in the Royal Ballet Company Shelly Pennefather (born ), American former professional basketball player, now a member of the Order of Saint Clare William Pennefather (1816–1873), British missionary
See also Pennefather River in Queensland, Australia, is located on western Cape York Peninsula