Pafford is a surname. Notable people with the surname include:
Caroline Pafford Miller (1903–1992), American writer Arch Pafford, politician in New Brunswick, Canada John Pafford (MP) John Henry Pyle Pafford (1900–1996), English librarian and soldier Mark Pafford (born 1966), Florida Democratic politician Ward B. Pafford (1911–2011), president of the University of West Georgia
See also Combe Pafford, village in Torbay in the English county of Devon Spafford