Pernell may refer to:
Given name Pernell (healer) (), English healer Pernell Cooper (1963–2016), American Paralympic powerlifter Pernell Davis (born 1976), American football defensive tackle Pernell McPhee (born 1988), American football linebacker Pernell Roberts (1928–2010), American stage, movie and television actor Pernell Saturnino, Grammy Award-winner percussionist from Curaçao Pernell Schultz (born 1994), Guyanese footballer Pernell Whitaker (1964–2019), American boxer and trainer
Surname Geoffrey Pernell, British soldier, rapist and murderer, along with two other soldiers, of Louise Jensen in 1994 in Cyprus LeRoy Pernell, American law professor and former dean Lia Pernell (born 1981), American rower Ruby Pernell (1917–2001), professor of social work at the University of Minnesota
Places Pernell, Oklahoma, United States, an unincorporated community