Puglisi () is an Italian surname, derived from (), the Sicilian language term to indicate someone from Apulia. Notable people with the surname include:
Andy Puglisi, American boy who disappeared in 1976 Gemma Puglisi, Italian-American author Leonardo Puglisi, Australian journalist Marcello Puglisi, Italian racing driver Onofrio Puglisi (d. 1679), Sicilian mathematician Pino Puglisi, Roman Catholic priest
See also Pugliesi, another surname