LSC may refer to:

Astronomy Local Supercluster Virgo Supercluster

Science and technology Lanthanum strontium cobaltate, see lanthanum strontium cobalt ferrite Luzon Science Consortium Shaped charge#Linear shaped charges LIGO Scientific Collaboration Message Sequence Chart#Live Sequence Charts Luminescent solar concentrator Lichen simplex chronicus LDAP Synchronization Connector, an open source software to synchronize an LDAP directory with any other data source. Landing Support Craft, a British WWII landing craft, US called Landing Craft Assault Landing Ship, Carrier (Derrick-Hoisting) a US WW2 landing craft with a crane.

Places Lafayette School Corporation, Indiana, US Lake Superior College, Duluth, Minnesota, US La Salle College, Hong Kong Lyndon State College, Vermont, US London School of Commerce, London, UK LSC, the IATA code for La Florida Airport, serving La Serena, Chile

Other LStar Capital, also known as LSC Film Corporation, a film production company that works with Sony Pictures Learning and Skills Council, former UK body Legal Services Commission, England, replaced by Legal Aid Agency Legal Services Corporation, US corporation providing legal aid Legend SuperCup, a legends car racing series since 2014 Lengua de Señas Colombiana, the Colombian sign language Llengua de Signes Catalana, the Catalan sign language Local School Councils, Chicago, US Local Swimming Committee, a subdivision of USA Swimming London Society of Compositors, former British trade union London Symphony Chorus, UK Lone Star Conference, an athletic conference affiliated in the Division II ranks of the National Collegiate Athletic Association (NCAA) LSC, a coupe model of the Continental Mark VII and Lincoln Mark VII