The Premios 40 Principales for Best Guatemalan Act was an honor presented annually at Los Premios 40 Principales between 2007 and 2011. It was then discontinued due to the creation of Los Premios 40 Principales América, reemerging in 2014 as part of them.
Year Winner Other nominees Los Premios 40 Principales España 2007Malacates Trébol Shop2008El Tambor de la Tribu2009Fabiola2010Duo Sway2011Los Reyes Vagos Los Premios 40 Principales América 2014 Piva
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