The Premios 40 Principales for Best Colombian Act was an honor presented annually at Los Premios 40 Principales from 2007 to 2011. It was discontinued due to the creation of Los Premios 40 Principales América, but reemerged in 2014 as part of this new award ceremony.
Year Winner Other nomineesLos Premios 40 Principales España 2007Sanalejo2008Katamarán2009Andrés Cepeda2010Santiago Cruz2011J BalvinLos Premios 40 Principales América2014Maluma
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