NLE is an acronym. It can refer to:
In education National Latin Exam, a test given to Latin students
Philippine Nursing Licensure Exam, a basic level nursing exam given in public schools in the Philippines
In science, medicine, and technology Non-linear editing system, a form of audio, video, and image editing N.L.E. Tractors, a codename for Cultivator No. 6
In transportation North Luzon Expressway, an expressway located in the Philippines The Northern line extension to Battersea, an underground extension project in London IATA code for Jerry Tyler Memorial Airport, Niles, Michigan
People NLE Choppa, an American rapper and his label No Love Entertainment
Sports National League East, a division of Major League Baseball