Hape is a surname. Notable people with the surname include:
Hape (tohunga), Polynesian navigator Janis Hape (1958–2021), American swimmer Patrick Hape (born 1974), American football player Shontayne Hape (born 1981), New Zealand rugby league and union player
See also R. v. Hape, Supreme Court of Canada case HapE is a synonym for Cysteine desulfurase, a hydrogen sulfide, alanine, and pyruvate producing enzyme High-altitude pulmonary edema, HAPE