Hanafin is a surname. Notable people with the surname include:
Des Hanafin (1930–2017), Irish politician John Hanafin (born 1960), Irish politician Lorcan Hanafin (born 2002), British racing driver Mary Hanafin (born 1959), Irish politician Ronan Hanafin (born 2004), American football player Will Hanafin, Irish journalist, television producer and radio personality