Pandolfini is an Italian family name. It may refer to:
Agnolo Pandolfini (1360-1446), Renaissance humanist Bruce Pandolfini (born 1947), American chess player and writer Egisto Pandolfini (1926–2019), Italian footballer Gianfranco Pandolfini (1920-1997), Italian water polo player, younger brother of Tullio Pandolfini Niccolò Pandolfini (1440-1518), Italian Roman Catholic bishop and cardinal Tullio Pandolfini (1914-1999), Italian water polo player Turi Pandolfini (1883-1962), Italian film actor
Other uses Villa Pandolfini, Renaissance villa near Florence, Italy