Mark DeSantis may refer to:
Mark DeSantis (businessman) (born 1959), American entrepreneur and political pundit Mark DeSantis (ice hockey) (born 1972), Canadian ice hockey defenceman and coach Marko DeSantis (born 1972), American lead guitarist for rock band Sugarcult Mark DeSantis, professor of finance, see Gunduz Caginalp Mark DeSantis, outside linebacker with the 1976, 1977, and 1978 Michigan Wolverines football teams