Pickworth is a surname. Notable people with the surname include:
Brian Pickworth (1929–2020), New Zealand fencer Henry Pickworth (c.1673?–c.1738), English religious controversialist Ossie Pickworth (1918–1969), Australian golfer Paul Pickworth (born 1958), English cricketer Samuel Pickworth Woodward (1821–1865), English geologist and malacologist