Wiffen is a surname. Notable people with the name include:

Benjamin Barron Wiffen (1794–1867), English Quaker businessman, bibliophile and biographer Daniel Wiffen (born 2001), Irish swimmer David Wiffen (1942–2026), Canadian singer-songwriter Daya Wiffen (born 1983), Danish netball player Jeremiah Holmes Wiffen (1792–1836), English poet and writer, brother of Benjamin Barron Wiffen Joan Wiffen (1922–2009), New Zealand amateur paleontologist Valerie Wiffen (born 1943), British artist

See also Whiffen, a surname